Skip to content
Catholic Online Logo

By Catholic Online (NEWS CONSORTIUM)

11/15/2012 (1 year ago)

Catholic Online (www.catholic.org)

Discovery hailed as the most influential gene discovery for Alzheimer's in past 20 years

Scientists in the United Kingdom have discovered a rare gene irregularity that has been found to increase by the threefold the risk of developing Alzheimer's disease. The finding has been declared to be the most influential gene discovery for Alzheimer's in the last 20 years.

The R47H mutation had a particularly strong association with the disease. R47H appeared in two percent of people with Alzheimer's compared to 0.5 per cent of people without the disease.

The R47H mutation had a particularly strong association with the disease. R47H appeared in two percent of people with Alzheimer's compared to 0.5 per cent of people without the disease.

Highlights

By Catholic Online (NEWS CONSORTIUM)

Catholic Online (www.catholic.org)

11/15/2012 (1 year ago)

Published in Health

Keywords: Alzhimer's, United Kingdom, research, defective gene, disease risk


LOS ANGELES, CA (Catholic Online) - The discovery may lead to an even greater understanding of the causes of the disease and may lead to new treatments.

Researchers studied data from more than 25,000 people to link a rare variant of the TREM2 gene to a higher risk of Alzheimer's. The gene is known to play a role in the immune system.

Headed by the Institute of Neurology, University College London or UCL, the findings have been published in the New England Journal of Medicine.

"These findings are particularly exciting because they give us a clear signal about what could be going wrong in Alzheimer's disease," study leader Dr. Rita Guerreiro says.

"While the genetic mutation we found is extremely rare, its effect on the immune system is a strong indicator that this system may be a key player in the disease.

"The more we can understand about the causes of Alzheimer's, the better our chances of developing treatments that could stop the disease developing."

Genes that increase the risk of Alzheimer's have been made previously, but they didn't explain entirely all of the genetic risk.

The researchers set out to uncover some of the rarer genetic variants involved in Alzheimer's, in a bid to get a clearer picture of the causes of the disease.

After sequencing the genes of 1,092 people with Alzheimer's and a control group of 1,107 healthy people they found several mutations in the TREM2 gene occurred more frequently in people who had Alzheimer's.

The R47H mutation had a particularly strong association with the disease. R47H appeared in two percent of people with Alzheimer's compared to 0.5 per cent of people without the disease.

The scientists confirmed their findings in two larger independent groups, analyzing data from a total of 6,675 people with Alzheimer's and 16,242 people without.

The mutation was found to be extremely rare, affecting just 0.3 per cent of the population, but increases the likelihood of developing Alzheimer's roughly three-fold. This is far more than any of the genes that have been linked to Alzheimer's in the last 20 years.

"Thanks to new advances in technology it's now possible to get a much more detailed look at the genetic risk for Alzheimer's, picking up rare variants like this one that were previously impossible to identify."

---


Pope Francis: end world hunger through 'Prayer and Action'


2014 - Distributed by THE NEWS CONSORTIUM

Pope Francis Prayer Intentions for October 2014
Peace:
That the Lord may grant peace to those parts of the world most battered by war and violence.
World Mission Day: That World Mission Day may rekindle in every believer zeal for carrying the Gospel into all the world.



Comments


More Health

Ebola can stay virulent on unclean surfaces for SEVEN WEEKS, scientists say Watch

Image of  Under certain conditions -- Ebola can survive on surfaces for almost TWO MONTHS.

By Catholic Online (NEWS CONSORTIUM)

As Ebola continues to ravage West Africa and make inroads in both Europe and the United States, an even more disheartening fact has been learned from experiments conducted four years ago. Under certain conditions -- Ebola can survive on surfaces for almost TWO ... continue reading


Tired of invasive colon tests? The Mayo Clinic may just have what you need Watch

Image of The Mayo Clinic has a new test for colon cancer that is less invasive or arduous than previous screening tests.

By Catholic Online (NEWS CONSORTIUM)

A new test from the Mayo Clinic may help those who find colon cancer screenings too invasive or arduous. LOS ANGELES, CA (Catholic Online) - The test is the first to look for cancer-causing genes in the DNA of a patient's stool, and was approved by the Food and Drug ... continue reading


Dallas nurse declared free of Ebola disease Watch

Image of

By CNA/EWTN News

Nina Pham, a Dallas nurse who has been battling Ebola after treating a patient in Texas, has now been declared free of the disease, and gave thanks to God and all those who have prayed for her in recent weeks. Washington D.C. (CNA/EWTN News) - "I feel fortunate and ... continue reading


People infected with Ebola sails past 10,000 mark - and half of them have died Watch

Image of The country hardest hit by the epidemic, Liberia, has compelled U.S. forces to build desperately needed treatment centers and help bring in aid.

By Catholic Online (NEWS CONSORTIUM)

It continues to spread unabated - according to the World Health Organization, more than 10,000 people have been infected with Ebola. Of those infected, nearly half of them have died. LOS ANGELES, CA (Catholic Online) - The rapidly rising death toll is occurring ... continue reading


Quarantined Ebola-positive doctor used subway, went to bowling alleys Watch

Image of Dr. Craig Spencer, an American doctor living in New York City, is under quarantine after testing positive for the Ebola virus.

By Catholic Online (NEWS CONSORTIUM)

As Dr. Craig Spencer, an American doctor living in New York City, is under quarantine after testing positive for the Ebola virus, officials are frantically tracking his steps throughout the city in order to see who could have been exposed. LOS ANGELES, CA ... continue reading


While death rates fall, tuberculosis still leaves millions stricken Watch

Image of The WHO said that insufficient funding was hampering efforts to combat the disease. An estimated $8 billion was needed each year.

By Catholic Online (NEWS CONSORTIUM)

For a completely curable disease, tuberculosis continues its deadly worldwide toll. The World Health Organization says that about 1.5 million people died in 2013 from TB, including 360,000 people who were HIV positive. The organization estimates that there are ... continue reading


Have we passed the tipping point? Drug resistant tuberculosis could kill millions Watch

Image of Tuberculosis, also known as the

By Catholic Online (NEWS CONSORTIUM)

The World Health Organization (WHO) has reported that multidrug resistant tuberculosis (TB) is reaching a tipping point, with about 480,000 new cases having occurred this year. LOS ANGELES, CA (Catholic Online) - The lung disease killed nearly 1.5 million people ... continue reading


What's the biggest danger in your home? It will shock and disgust you Watch

Image of Kitchen towels in your home may be the biggest danger to the health of you and your family.

By Catholic Online (NEWS CONSORTIUM)

The biggest danger in your house aren't stairs, bugs or chemicals, but actually may be hand towels kept in the kitchen. LOS ANGELES, CA (Catholic Online) - Kitchen towels may spread food poisoning, bacteria or other dangerous microorganisms around your home without any ... continue reading


NOT long enough: Ebola could lay dormant in the body for longer than 21 days, expert claims Watch

Image of Biology Professor Charles Hass, who has vast experience of analyzing the risk of transmitting biological pathogens, said

By Catholic Online (NEWS CONSORTIUM)

A new study warns that the recommended 21-day quarantine period for the Ebola virus is not long enough to contain the spread of the disease. While the World Health Organization advises the incubation period for the virus is between two and 21 days, scientists ... continue reading


Nurse says Texas Presbyterian Hospital was chaotic and filthy during Ebola outbreak Watch

Image of

By Catholic Online (NEWS CONSORTIUM)

Texas Presbyterian Hospital in Dallas, Texas, reacted very poorly when it discovered that they had been treating a Liberian man with Ebola. According to a nurse who has since come forward, safety regulations were blithely ignored, contaminated linens and waste ... continue reading


All Health News

Newsletters

Newsletter Sign Up icon

Stay up to date with the latest news, information, and special offers

Daily Readings

Reading 1, Philippians 1:1-11
1 Paul and Timothy, servants of Christ Jesus, to all ... Read More

Psalm, Psalms 111:1-2, 3-4, 5-6
1 Alleluia! I give thanks to Yahweh with all my ... Read More

Gospel, Luke 14:1-6
1 Now it happened that on a Sabbath day he had gone ... Read More

Saint of the Day

Saint of the Day for October 31st, 2014 Image

St. Wolfgang
October 31: Wolfgang (d. 994) + Bishop and reformer. Born in Swabia, ... Read More

Inform, Inspire & Ignite Logo

Find Catholic Online on Facebook and get updates right in your live feed.

Become a fan of Catholic Online on Facebook


Follow Catholic Online on Twitter and get News and Product updates.

Follow us on Twitter